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Digital microfluidics: A promising technique for biochemical applications
He WANG, Liguo CHEN, Lining SUN
Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4, Pages 510-525 doi: 10.1007/s11465-017-0460-z
Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application
Keywords: digital microfluidics electrowetting on dielectric discrete droplet biochemistry
Frontiers of Chemical Science and Engineering Pages 1643-1650 doi: 10.1007/s11705-022-2201-z
Keywords: microcapsule emulsion microfluidics selective permeation stimuli-triggered release
Microfluidics for Medical Additive Manufacturing Review
Jie Wang, Changmin Shao, Yuetong Wang, Lingyun Sun, Yuanjin Zhao
Engineering 2020, Volume 6, Issue 11, Pages 1244-1257 doi: 10.1016/j.eng.2020.10.001
Keywords: Microfluidics Biomaterial Additive manufacturing Droplet Fiber
Microfluidic production of liposomes through liquid–liquid phase separation in ternary droplets
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6, Pages 1017-1022 doi: 10.1007/s11705-021-2118-y
Keywords: microfluidics liposomes ternary droplets phase separation
Mechanically Strong Proteinaceous Fibers: Engineered Fabrication by Microfluidics Review
Jing Sun, Jingsi Chen, Kai Liu, Hongbo Zeng
Engineering 2021, Volume 7, Issue 5, Pages 615-623 doi: 10.1016/j.eng.2021.02.005
Keywords: Proteinaceous fibers Microfluidics Soft materia l Biomaterials
Microfluidics for cell-cell interactions: A review
Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 90-98 doi: 10.1007/s11705-015-1550-2
Keywords: microfluidic chip co-culture cell-cell interactions review
Changmin Shao, Yuxiao Liu, Junjie Chi, Fangfu Ye, Yuanjin Zhao
Engineering 2021, Volume 7, Issue 12, Pages 1778-1785 doi: 10.1016/j.eng.2020.06.031
With the advantages of better mimicking the specificity of natural tissues, three-dimensional (3D) cell culture plays a major role in drug development, toxicity testing, and tissue engineering. However, existing scaffolds or microcarriers for 3D cell culture are often limited in size and show suboptimal performance in simulating the vascular complexes of living organisms. Therefore, we present a novel hierarchically inverse opal porous scaffold made via a simple microfluidic approach for promoting 3D cell co-culture techniques. The designed scaffold is constructed using a combined concept involving an emulsion droplet template and inert polymer polymerization. This work demonstrates that the resultant scaffolds ensure a sufficient supply of nutrients during cell culture, so as to achieve large-volume cell culture. In addition, by serially planting different cells in the scaffold, a 3D co-culture system of endothelial-cell-encapsulated hepatocytes can be developed for constructing certain functional tissues. It is also demonstrated that the use of the proposed scaffold for a co-culture system helps hepatocytes to maintain specific in vivo functions. These hierarchically inverse opal scaffolds lay the foundation for 3D cell culture and even the construction of biomimetic tissues.
Keywords: Microfluidics Inverse opal Cell culture Droplet Biomaterial
Modeling and simulation of droplet translocation and fission by electrowetting-on-dielectrics (EWOD)
Nathan HOWELL, Weihua LI
Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4, Pages 376-388 doi: 10.1007/s11465-010-0104-z
Keywords: electrowetting-on-dielectrics (EWOD) electrowetting microfluidics droplet translocation droplet fission
Rotation of Biological Cells: Fundamentals and Applications Review
Tao Tang, Yoichiroh Hosokawa, Takeshi Hayakawa, Yo Tanaka, Weihua Li, Ming Li, Yaxiaer Yalikun
Engineering 2022, Volume 10, Issue 3, Pages 110-126 doi: 10.1016/j.eng.2020.07.031
Cell rotation is one of the most important techniques for cell manipulation in modern bioscience, as it not only permits cell observation from any arbitrary angle, but also simplifies the procedures for analyzing the mechanical properties of cells, characterizing cell physiology, and performing microsurgery. Numerous approaches have been reported for rotating cells in a wide range of academic and industrial applications. Among them, the most popular are micro-robot-based direct contact manipulation and field-based non-contact methods (e.g., optical, magnetic, electric, acoustic, and hydrodynamic methods). This review first summarizes the fundamental mechanisms, merits, and demerits of these six main groups of approaches, and then discusses their differences and limitations in detail. We aim to bridge the gap between each method and illustrate the development progress, current advances, and prospects in the field of cell rotation.
Keywords: Cell rotation Cell reorientation Micromanipulation Microfluidics
Microfluidic dual loops reactor for conducting a multistep reaction
Si Hyung Jin, Jae-Hoon Jung, Seong-Geun Jeong, Jongmin Kim, Tae Jung Park, Chang-Soo Lee
Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2, Pages 239-246 doi: 10.1007/s11705-017-1680-9
Keywords: microfluidics multistep reaction rotary mixing nanoparticle
A review on emulsification via microfluidic processes
Yichen Liu, Yongli Li, Andreas Hensel, Juergen J. Brandner, Kai zhang, Xiaoze Du, Yongping Yang
Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3, Pages 350-364 doi: 10.1007/s11705-019-1894-0
Keywords: microfluidics emulsification capillary number droplet breakup
Ionically Imprinting-Based Copper (Ⅱ) Label-Free Detection for Preventing Hearing Loss Article
Huan Wang, Hui Zhang, Xiaoli Zhang, Hong Chen, Ling Lu, Renjie Chai
Engineering doi: 10.1016/j.eng.2023.09.001
Copper is a microelement with important physiological functions in the body. However, the excess copper ion (Cu2+) may cause severe health problems, such as hair cell apoptosis and the resultant hearing loss. Therefore, the assay of Cu2+ is important. We integrate ionic imprinting technology (IIT) and structurally colored hydrogel beads to prepare chitosan-based ionically imprinted hydrogel beads (IIHBs) as a low-cost and high-specificity platform for Cu2+ detection. The IIHBs have a macroporous microstructure, uniform size, vivid structural color, and magnetic responsiveness. When incubated in solution, IIHBs recognize Cu2+ and exhibit a reflective peak change, thereby achieving label-free detection. In addition, benefiting from the IIT, the IIHBs display good specificity and selectivity and have an imprinting factor of 19.14 at 100 lmol∙L–1. These features indicated that the developed IIHBs are promising candidates for Cu2+ detection, particularly for the prevention of hearing loss.
Keywords: Structural color Microfluidics Ionic imprinting Label-free detection Hearing loss
Hongzhan Di, Gregory J. O. Martin, Dave E. Dunstan
Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3, Pages 552-561 doi: 10.1007/s11705-020-1962-5
Keywords: particle deposition crossflow filtration microfluidics confocal microscopy
A Versatile Flow-Profile Engineering Method in the Stokes Flow Regime for Complex-Shaped Flows Article
Zhenyu Yang, Lang Nan, Ho Cheung Shum
Engineering 2021, Volume 7, Issue 5, Pages 655-662 doi: 10.1016/j.eng.2021.02.008
Flow profiles are frequently engineered in microfluidic channels for enhanced mixing, reaction control, and material synthesis. Conventionally, flow profiles are engineered by inducing inertial secondary flow to redistribute the streams, which can hardly be reproduced in microfluidic environments with negligible inertial flow. The employed symmetric channel structures also limit the variety of achievable flow profiles. Moreover, each of the flow profiles specifically corresponds to a strictly defined flow condition and cannot be generalized to other flow environments. To address these issues, we present a systematic method to engineer the flow profile using inertialess secondary flow. The flow is manipulated in the Stokes regime by deploying a cascaded series of microsteps with various morphologies inside a microchannel to shape the flow profile. By tuning the shapes of the microsteps, arbitrary outflow profiles can be customized. A numerical profile-transformation program is developed for rapid prediction of the output profiles of arbitrary sequences of predefined microsteps. The proposed method allows the engineering of stable flow profiles, including asymmetric ones, over a wide range of flow conditions for complex microfluidic environmental prediction and design.
Keywords: Microfluidics Flow profile Stokes flow Hydrodynamic focusing Flow shaping
Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface
Marc Mac Giolla Eain, Joanna Baginska, Kacy Greenhalgh, Joëlle V. Fritz, Frederic Zenhausern, Paul Wilmes
Engineering 2017, Volume 3, Issue 1, Pages 60-65 doi: 10.1016/J.ENG.2017.01.011
Keywords: Microbiome Microfluidics Organ-on-a-chip HuMiX
Title Author Date Type Operation
Digital microfluidics: A promising technique for biochemical applications
He WANG, Liguo CHEN, Lining SUN
Journal Article
Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered
Journal Article
Microfluidics for Medical Additive Manufacturing
Jie Wang, Changmin Shao, Yuetong Wang, Lingyun Sun, Yuanjin Zhao
Journal Article
Microfluidic production of liposomes through liquid–liquid phase separation in ternary droplets
Journal Article
Mechanically Strong Proteinaceous Fibers: Engineered Fabrication by Microfluidics
Jing Sun, Jingsi Chen, Kai Liu, Hongbo Zeng
Journal Article
Microfluidics for cell-cell interactions: A review
Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng
Journal Article
Hierarchically Inverse Opal Porous Scaffolds from Droplet Microfluidics for Biomimetic 3D Cell Co-Culture
Changmin Shao, Yuxiao Liu, Junjie Chi, Fangfu Ye, Yuanjin Zhao
Journal Article
Modeling and simulation of droplet translocation and fission by electrowetting-on-dielectrics (EWOD)
Nathan HOWELL, Weihua LI
Journal Article
Rotation of Biological Cells: Fundamentals and Applications
Tao Tang, Yoichiroh Hosokawa, Takeshi Hayakawa, Yo Tanaka, Weihua Li, Ming Li, Yaxiaer Yalikun
Journal Article
Microfluidic dual loops reactor for conducting a multistep reaction
Si Hyung Jin, Jae-Hoon Jung, Seong-Geun Jeong, Jongmin Kim, Tae Jung Park, Chang-Soo Lee
Journal Article
A review on emulsification via microfluidic processes
Yichen Liu, Yongli Li, Andreas Hensel, Juergen J. Brandner, Kai zhang, Xiaoze Du, Yongping Yang
Journal Article
Ionically Imprinting-Based Copper (Ⅱ) Label-Free Detection for Preventing Hearing Loss
Huan Wang, Hui Zhang, Xiaoli Zhang, Hong Chen, Ling Lu, Renjie Chai
Journal Article
Characterization of particle deposition during crossflow filtration as influenced by permeate flux and crossflow velocity using a microfluidic filtration system
Hongzhan Di, Gregory J. O. Martin, Dave E. Dunstan
Journal Article
A Versatile Flow-Profile Engineering Method in the Stokes Flow Regime for Complex-Shaped Flows
Zhenyu Yang, Lang Nan, Ho Cheung Shum
Journal Article